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Research on ALS, a debilitating condition also known as Lou Gehrig's disease that leads to muscle weakness and death, has found a link between exposure to pesticides and disease development. A new study led by ... Alison O'Neil provides insight into how a specific pesticide damages the nerve cells affected in ALS patients. The paper, published in the prestigious multidisciplinary journal PLOS One, is a follow up to another study O'Neil conducted on the pesticide known as cis-chlordane, which is banned but persists in the environment. "The goal of the study was to try to figure out why cis-chlordane is able to kill motor neurons," which are the nerve cells that die in ALS (amyotrophic lateral sclerosis), she said. "It turns out that [the pesticides] are affecting the mitochondria, which are the powerhouse of the cell," said O'Neil. Without mitochondria, the motor neurons weaken and die. This insight points to potential for more effective treatments for a disease when current therapies extend life by only a few months. "The implications of that finding helps us determine what kind of drugs people need," said O'Neil. Since there is clearly an environmental component in most cases of ALS, said Clackson, the research can help pinpoint what is contributing to the disease and potentially change disease trajectory. "If we see these early biomarkers, say pesticides in the blood, then we can perhaps treat them earlier and have a completely different outcome," he said.
Note: It's recently come out that the popular pesticide paraquat probably causes Parkinson's disease. For more along these lines, read our concise summaries of news articles on health and toxic chemicals.
Imet my best friend, Ursula Guidry, in college. Ursula died from cancer when her children were in preschool. We'll never know if her death was pure "bad luck," or whether it had something to do with growing up amidst plastics-manufacturing facilities. What we know for certain is that the toxic chemicals emitted by those facilities can ravage the human body. It's against that backdrop that I watch Environmental Protection Agency Administrator Lee Zeldin work feverishly to dismantle the safeguards protecting people from toxic chemical exposures. The U.S. averages one chemical spill, fire, or explosion every three days, but Zeldin's attacks almost guarantee an increase. Every part of the petrochemical supply chain puts communities at risk, including the nation's millions of miles of pipelines. In Satartia, Miss., a pipeline carrying carbon dioxide used in oil drilling ruptured from heavy rains and floods, spewing carbon dioxide for hours. The carbon dioxide displaced oxygen in the air, so car engines stopped running and people could not escape. Dozens were hospitalized. Acute CO2 emissions cause heart malfunction and death by asphyxiation. Extreme flooding can also submerge Superfund toxic waste dumps. Nearly 1 in 4 Americans live within three miles of a Superfund site. Zeldin's plans are a gift to the fossil fuel and petrochemical corporations. For the rest of us, they are an explosive and hostile attack on our children, our families, and our best friends.
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The city of San Francisco filed the nation's first government lawsuit against some of the largest manufacturers of ultra-processed foods on Tuesday, asserting that the 10 corporations knew the products were harming Americans' health but continued to market them anyway. The corporations include cereal giants Kellogg, Post Holdings and General Mills, candy makers NestlĂ© USA and Mars Incorporated, the soda companies behind Coca-Cola and PepsiCo, as well as Kraft Heinz Company, ConAgra Brands and Mondelz International. The suit argues that the health care costs of treating related health conditions tied to consuming ultra-processed foods – upwards of $100 billion a year – have fallen on Americans, cities and states. "These companies created a public health crisis with the engineering and marketing of ultra-processed foods," San Francisco City Attorney David Chiu said. "They took food and made it unrecognizable and harmful to the human body." "We must be clear that this is not about consumers making better choices. Recent surveys show Americans want to avoid ultra-processed foods, but we are inundated by them. These companies engineered a public health crisis, they profited handsomely, and now they need to take responsibility for the harm they have caused," he added. Some 70 percent of the U.S. food supply is ultra-processed, according to the U.S. Food and Drug Administration.
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November 30 marks the International Day of Remembrance for all Victims of Chemical Warfare. Between 1961 and 1971, the U.S. military sprayed an estimated 20 million gallons of herbicides over southern Vietnam, along the Ho Chi Minh Trail in Laos, and parts of Cambodia. Nearly two-thirds was Agent Orange, later discovered to be contaminated with 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) – a potent, long-lasting dioxin. TCDD is a known human carcinogen and an endocrine disruptor, linked to cancers, reproductive disorders, and birth defects that can span generations. By the letter of the CWC, Agent Orange is not classified as a "chemical weapon." If you ask a Vietnam veteran suffering from Parkinson's, cancer, heart disease, or any of the 19 types of conditions the Department of Veterans Affairs (VA) associates with Agent Orange exposure, you'll hear a very different story. To them, it was every bit a weapon designed to destroy life and health. A 2018 Government Accountability Office report found that over 757,000 veterans – about one in four who served – were receiving benefits linked to Agent Orange. The 2022 PACT Act broadened that circle to veterans who served in other areas where Agent Orange was used. By 2024, more than 84,000 new Vietnam-era veterans were granted compensation, many due to exposure. Fifty years after the Vietnam War ended, the toxic legacy of Agent Orange and other dioxins lingers on.
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The World Health Organization's cancer research agency has classified atrazine – the second most widely used herbicide in the United States – as "probably carcinogenic to humans," adding to growing concerns about toxic exposures in the nation's farm belt. The evaluation means the first and second most widely used herbicides in the U.S. – glyphosate and atrazine – are now both considered probable human carcinogens by the world's leading independent cancer-hazard authority. Atrazine is banned in the European Union and other countries due to health and environmental concerns, but remains widely used in the U.S., where it is a common contaminant in drinking water, according to the Environmental Protection Agency. Despite these concerns, U.S. regulators allow its continued use. The new assessment by the WHO's cancer agency comes 10 years after the agency's landmark finding that glyphosate, the world's most heavily used herbicide, is also "probably carcinogenic to humans." Both atrazine and glyphosate are also endocrine disruptors, meaning they can disrupt key hormone systems that regulate growth, development and metabolism. Both herbicides are also largely produced by companies outside the United States. Syngenta, owned by ChemChina, produces most of the atrazine used in the U.S., while Bayer, based in Germany, is the dominant producer of glyphosate. The cancer designation for atrazine comes amid reports of rising cancer rates across the U.S. Corn Belt.
Note: It's recently come out that the popular pesticide paraquat probably causes Parkinson's disease. For more along these lines, read our concise summaries of news articles on health and toxic chemicals.
Children who spend more time on mobile phones, TVs, and video games may face a higher risk of developing attention problems as they grow, according to a first-of-its kind, large-scale study. The findings, recently published in Translational Psychiatry ... indicate a link between longer screen time and more severe symptoms of attention-deficit/hyperactivity disorder (ADHD). Researchers ... also found measurable, though subtle, brain abnormalities among heavy screen users. Longer screen time at ages 9–10 predicted higher ADHD symptoms two years later. Higher screen time was linked to a smaller cortex, the outer layer of the brain responsible for higher-level thinking and attention. Children with more screen time at the outset had a smaller right putamen, a region involved in language learning, addiction, and reward processing. Heavier screen use after two years was tied to slightly thinner development in three other cortical regions that support important cognitive functions, such as attention, working memory, and language processing. Screen use has increased worldwide among children and adolescents, with more than one-third of U.S. parents of a child under 12 reporting their children began interacting with a smartphone before the age of 5. While digital devices are promoted as essential tools for school and social connection, their excessive use has been tied to disrupted sleep, reduced physical activity and negative impacts on mental health.
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Ultra-processed food (UPF) is linked to harm in every major organ system of the human body and poses a seismic threat to global health. UPF is also rapidly displacing fresh food in the diets of children and adults on every continent, and is associated with an increased risk of a dozen health conditions, including obesity, type 2 diabetes, heart disease and depression. The findings, from a series of three papers published in the Lancet, come as millions of people increasingly consume UPF such as ready meals, cereals, protein bars, fizzy drinks and fast food. In the UK and US, more than half the average diet now consists of UPF. For some, especially people who are younger, poorer or from disadvantaged areas, a diet comprising as much as 80% UPF is typical. Evidence reviewed by 43 of the world's leading experts suggests that diets high in UPF are linked to overeating, poor nutritional quality and higher exposure to harmful chemicals and additives. A systematic review of 104 long-term studies conducted for the series found 92 reported greater associated risks of one or more chronic diseases, and early death from all causes. One of the Lancet series authors, Prof Carlos Monteiro ... said the findings underlined why urgent action is needed to tackle UPF. "The first paper in this Lancet series indicates that ultra-processed foods harm every major organ system in the human body. The evidence strongly suggests that humans are not biologically adapted to consume them."
Note: For more along these lines, read our concise summaries of news articles on health and food system corruption.
Marie began taking fluoxetine, the generic form of Prozac, when she was 15. The drug – an S.S.R.I., a selective serotonin reuptake inhibitor – was part of her treatment in an outpatient program for an eating disorder. It took its toll on her sexuality. Marie told me she has PSSD, post-S.S.R.I. sexual dysfunction, a loss of sexuality that persists after the drug is no longer being taken. Clinicians have published more than 500 case reports in academic literature about the experience of PSSD. A 2020 editorial in The British Medical Journal argued, "Post-S.S.R.I. sexual dysfunction is underrecognized and can be debilitating both psychologically and physically." The effects of S.S.R.I.s on young sexuality are all the more relevant because prescriptions for the drugs have soared. Around two million 12-to-17-year-olds in the United States are on S.S.R.I.s. One large 2024 study ... tallied, month by month, the percentage of that age group who filled an antidepressant prescription between 2016 and 2022. During that time, the rate climbed by 69 percent. There are no dedicated studies of sexual side effects among the young. All that is available is extrapolation from research among adults. Depending on the symptom, drug and duration of use, between 30 and 80 percent of adults taking S.S.R.I.s live to varying degrees with diminished desire, sensation and function, according to a 2019 study.
Note: For more along these lines, read our concise summaries of news articles on Big Pharma profiteering and mental health.
In 2001, the Journal of the American Academy of Child & Adolescent Psychiatry (JAACAP) published a paper declaring that the antidepressant paroxetine (Paxil) was "generally well tolerated and effective" for adolescent depression. That conclusion was false. The manufacturer, GlaxoSmithKline (GSK), knew from its own data that the drug failed to outperform placebo and carried a serious risk of suicidal behaviour. Instead of telling the truth, GSK hired a public-relations firm to ghostwrite the paper, enlisted academic co-authors who never saw the raw data, and used the publication to promote Paxil to doctors treating children. It became known as Study 329 – one of the most infamous cases of scientific fraud in modern psychiatry. The paper remained in circulation – cited hundreds of times, shaping prescribing habits, and legitimising a lie that cost young lives. The paper listed 22 authors – two were GSK employees, and most had never reviewed the raw data or disclosed their financial ties to the company. Once the article appeared in print, GSK's sales force distributed it to thousands of doctors as "proof" that Paxil worked in teens. Within three years, the company made more than a billion dollars from what it called the "adolescent market." In 2003, the FDA concluded: "There is currently no evidence that Paxil is effective in children and adolescents with major depressive disorder." In 2012, GSK pleaded guilty and paid a $3 billion settlement to resolve criminal and civil charges.
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Susan Abookire, an internist and professor at Harvard Medical School, had a cure for all that ailed me. "Find a being. The being might be a tree or rock," she told me. "Greet it as you would a friend. You might want to introduce yourself. You may want to share something with that being." I was participating, somewhat skeptically, in a forest bathing session Abookire was leading at Harvard's Arnold Arboretum for seven young doctors. It's part of resident training ... which is looking for ways to reduce stress and burnout within the profession. She explained that just by standing among the trees, we were inhaling essential tree oils called phytoncides and aromatic plant compounds called terpenes. "There's several studies now showing that inhaling phytoncides boosts our immune system, and specifically our natural killer-cell numbers and activities go up," she said. Breathing in tree scents fights infection, prevents cancer and protects against dementia. Qing Li, a professor at Japan's Nippon Medical School ... told me, "the larger the trees, the higher the tree density, and the larger the forest area, the greater the effects of forest bathing." More phytoncides and more terpenes, more benefit. He also believes we profit from inhaling negative ions (found in abundance near waterfalls) as well as a microorganism found in the soil, Mycobacterium vaccae. He recommends spending two to four hours in the forest walking at a slow pace ... and paying attention to your senses.
Note: Explore more positive stories like this in our comprehensive healing our bodies and healing the Earth.
It was early 2012 when doctors found a tumor in Kim Franzi's brain. Franzi underwent a risky two-day brain surgery to remove the mass, which doctors warned could leave her paralyzed or prove fatal. The operation was successful, but more than 13 years later, she still suffers from side effects, including issues with her reflexes, teeth, hearing, and vision. Before discovering the tumor, Franzi used the birth control shot Depo-Provera for more than 15 years. The shot has been used by roughly one in four sexually active women in the United States, bringing in hundreds of millions in profits annually for the pharmaceutical behemoth Pfizer, which manufactures and distributes the drug. But according to more than 1,200 lawsuits, Pfizer has failed to properly warn the public about long-established links between Depo-Provera and meningiomas. That includes a lawsuit submitted on Franzi's behalf, plus more than 9,500 cases that have yet to be filed. In 2024, a large study of more than 18,000 cases of women undergoing surgery for meningiomas found that "prolonged use of [Depo-Provera] was found to increase the risk of intracranial meningioma." Specifically, the scientists found that use of Depo-Provera was associated with a more than five-fold heightened risk of developing a meningioma that required surgery, and that risk increased further if patients used Depo-Provera for more than a year. Drug labels for Depo-Provera in the European Union, United Kingdom, New Zealand, Australia, and Canada ... warn about these brain tumors.
Note: Read the full article to learn about how Pfizer omitted six studies that found significant links between patients taking the birth control shot and brain tumors. For more along these lines, read our concise summaries of news articles on health and Big Pharma corruption.
Emergency rooms, dentist offices, and nursing homes managed by the private equity industry consistently deliver worse health outcomes than other such medical institutions. The difference can mean life or death for patients. A new Harvard Medical School study of more than one million Medicare ER visits found that patient death rates are 13 percent higher in private equity–owned ERs than their counterparts, likely thanks to staffing and salary cuts. On average, private equity–owned hospitals reduce hospital staffing by more than 11 percent and pay ER staffers 18 percent less than non-private equity hospitals. Private equity–backed dental groups have been found to perform medically unnecessary and painful procedures. One firm allegedly extracted healthy teeth from patients to charge them for expensive dental implants, while another performed root canals on the baby teeth of children as young as three. A study of more than 662,000 Medicare hospitalizations in private equity–owned facilities saw 25 percent more hospital-acquired complications, including falls and surgical site infections, compared to other hospitals. Medicare patients in private equity–backed nursing homes suffered an 11 percent higher short-term mortality rate than those in non-private equity–backed facilities between 2004 and 2019, resulting in 22,500 additional deaths. Nursing homes linked to private equity tend to underperform in terms of patient mobility and reported pain levels.
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Robert F. Kennedy Jr.'s making animal welfare a component of his Make America Healthy Again mission. The health secretary has asked his agencies to refine high-tech methods of testing chemicals and drugs that don't involve killing animals. He thinks phasing out animal testing and using the new methods will help figure out what's causing chronic disease. Last week, the National Institutes of Health announced it would spend $87 million on a new center researching alternatives to animal testing and permit agency-supported researchers to use grant funding to find homes for retired lab animals. Kennedy signed off because he thinks the new methods will enable scientists to more quickly and inexpensively draw conclusions about how chemicals and drugs work. He expects that'll confirm his belief that chemicals in the environment and in food are making Americans sick and also speed cures for chronic diseases like cancer, heart disease and diabetes. The new center will attempt to develop a standardized alternative to animal testing that relies on tiny, lab-grown 3D tissue models, enlisting help from across the NIH and the Food and Drug Administration, which regulates pharmaceuticals. Harnessing science and technology to protect animals isn't an obvious Trump agenda item. But the president has a pattern of taking ideas from the left and repackaging them for his base, to great success.
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Professor Michael Antoniou, head of the Gene Expression and Therapy Group at King's College London, has studied for more than 35 years how genes function and how they are disrupted. His decades of rigorous independent research into the risks of GM foods and glyphosate-based herbicides have raised serious concerns about the safety of these technologies. In a report he prepared for the Mexican government, as the country attempted to restrict GMO corn imports for health reasons, Professor Antoniou cited "a large body of evidence from well-controlled laboratory animal toxicity studies that show evidence of harm to multiple physiological systems" from toxic agents found in GM corn. The health risks of GM corn and its associated pesticides arise from three main sources: Bt insecticidal proteins engineered into the plants, DNA damage caused by the genetic modification process itself, and pesticides used on the crops. The GM transformation process – the process by which a GMO is generated in the laboratory – is highly mutagenic. You create unintended damage to the DNA of the crop. And by changing the pattern of gene function in the organism, you will change its biochemistry and its composition, including the unexpected production of new toxins and allergens. Regardless of the GMO crop we're talking about, they're all grown with one or more different kinds of pesticides ... such as glyphosate. They invariably come with pesticide residues
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Pesticides once appeared to be a clear target for Robert F. Kennedy Jr.'s desire to "make America healthy again." Before becoming the health secretary, he described Monsanto, the maker of the glyphosate-based herbicide Roundup, as "enemy of every admirable American value," and vowed to "ban the worst agricultural chemicals already banned in other countries." Since he came to power, many of Kennedy's fans have waited eagerly for him to do just that. Kennedy has yet to satisfy them: In the latest MAHA action plan on children's health, released last week, pesticides appear only briefly on a laundry list of vague ideas. The plan says that the government should fund research on how farmers could use less of them, and that the government "will work to ensure that the public has awareness and confidence" in the EPA's existing pesticide-review process, which it called "robust." Several studies have found neurological impacts associated with pesticides. UC Davis's MIND Institute put out a study in 2014 that found autism risk was much higher among children whose mothers had lived near agricultural-pesticide areas while pregnant. A 2017 paper found that zip codes that conducted aerial spraying for mosquitoes–a pesticide–had comparatively higher rates of autism than zip codes that didn't. Others have linked pesticides to a range of behavioral and cognitive impairment in children.
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Pesticides banned years ago in the European Union are drifting through the skies and turning up in clouds above France, raising concerns about how long these toxins persist and how far they can travel, with potentially harmful global health impacts, according to a pathbreaking new study. The research ... is the first to detect dozens of agricultural chemicals–including insecticides, herbicides, fungicides, and other substances–suspended in cloud water droplets. That means pesticides not only linger in the environment but also move through the atmosphere and fall back to Earth in rain or snow, sometimes at levels exceeding European safe drinking water limits. The study found that clouds can carry current-use pesticides, long-banned compounds, and "emerging contaminants"–industrial chemicals that either build up in the environment or form when older pesticides break down. Some even transform into new compounds in the atmosphere itself, beyond what regulators have known to consider. Researchers estimate that French skies alone may contain anywhere from a few tons to more than 100 tons of pesticides at any given time–most carried in from distant sources. Out of 446 possible chemicals screened–including pesticides, biocides (compounds that kill harmful organisms), additives, and transformation products (breakdown products of pesticides)–researchers found 32 different compounds in cloud water.
Note: Across the US, a powerful legislative push is underway to protect pesticide manufacturers from being held accountable for the harms caused by their products. Check out our latest Substack, "The Pesticide Crisis Reveals The Dark Side of Science. We Have The Solutions to Regenerate."
When it comes to pesticides, the Trump administration's Make America Healthy Again, or MAHA, Commission has a serious problem: The Commission's newly released strategy for addressing childhood chronic disease is better for the pesticide industry than for people. The US currently uses over a billion pounds of pesticides annually on our crops, about one-third of which is chemicals that have been banned in other countries. Many have been linked to serious health problems from cancer to infertility to birth defects. Those pesticides contaminate our air, our water, and our bodies. One cancer-linked pesticide, glyphosate, is now found in 80% of adults and 87% of children. [The Commission] barely mentions organic farming, despite the fact that organic is the clearest pathway to transforming our food system into one that is healthy and nontoxic. The US Department of Agriculture organic seal prohibits more than 900 synthetic pesticides allowed in conventional agriculture. Just one week on an organic diet can reduce pesticide levels in our bodies up to 95%. Synthetic food dyes–a key issue for the MAHA movement–are all prohibited by the organic seal, along with hundreds of other food additives and drugs. The Commission's strategy ignores organic. Instead, it leans into promoting industry-friendly "precision agriculture"–the use of AI, machine learning, and digital tools on farms to optimize inputs–which primarily benefits corporate giants like Bayer.
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More children around the world are obese than underweight for the first time, according to a UN report that warns ultra-processed junk food is overwhelming childhood diets. There are 188 million teenagers and school-age children with obesity – one in 10 – Unicef said, affecting health and development and bringing a risk of life-threatening diseases. Catherine Russell, executive director of the UN agency for children, said: "When we talk about malnutrition, we are no longer just talking about underweight children. "Obesity is a growing concern. Ultra-processed food [UPF] is increasingly replacing fruits, vegetables and protein at a time when nutrition plays a critical role in children's growth, cognitive development and mental health." While 9.2% of five to 19-year-olds worldwide are underweight, 9.4% are considered obese, the report found. In 2000, nearly 13% were underweight and just 3% were obese. Obesity has overtaken being underweight as the more prevalent form of malnutrition in all regions of the world except sub-Saharan Africa and South Asia, and is a problem even in countries with high numbers of children suffering from wasting or stunting due to a lack of food. One in five of those aged between five and 19 are overweight, with a growing proportion of those 291 million individuals falling into the obese category: 42% in 2022, up from 30% in 2000. Childhood obesity has been linked to higher risks of heart disease, type 2 diabetes and some cancers in later life.
Note: Read our latest Substack article on how the US government turns a blind eye to the corporate cartels fueling the chronic health crisis. For more along these lines, read our concise summaries of news articles on health and food system corruption.
Despite the increasing rate of allergic diseases, both in industrialized and in developing countries, the Amish remain exceptionally – and bafflingly – resistant. Only 7 percent of Amish children had a positive response to one or more common allergens in a skin prick test, compared with more than half of the general U.S. population. Even children from other traditional farming families, who still have lower rates of allergic disease than nonfarm children, are more allergic than the Amish. "Certain kinds of farming practices, particularly the very traditional ones, have this extraordinary protective effect in the sense that, in these communities, asthma and allergies are virtually unknown," said Donata Vercelli, a professor of cellular and molecular medicine. "The studies that have been done in these farming populations are critical because they tell us that protection is an attainable goal." During the first year or two of life, a baby's immune system is rapidly developing and highly malleable by environmental stimuli, such as bacteria. Some experts believe that exposing young children to certain types of beneficial bacteria can engage and shape the growing immune system in a way that reduces the risk of allergic diseases later in life. Farm dust contains a hodgepodge of bacteria shed from livestock and animal feed that isn't harmful enough to cause illness, but does effectively train the immune system to become less responsive to allergens later in life.
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The insecticide chlorpyrifos is a powerful tool for controlling various pests, making it one of the most widely used pesticides during the latter half of the 20th century. Like many pesticides, however, chlorpyrifos lacks precision. In addition to harming non-target insects like bees, it has also been linked to health risks for much larger animals – including us. Now, a new US study suggests those risks may begin before birth. Humans exposed to chlorpyrifos prenatally are more likely to exhibit structural brain abnormalities and reduced motor functions in childhood and adolescence. Progressively higher prenatal exposure to chlorpyrifos was associated with incrementally greater deviations in brain structure, function, and metabolism in children and teens, the researchers found, along with poorer measures of motor speed and motor programming. This supports previous research linking chlorpyrifos with impaired cognitive function and brain development, but these findings are the first evidence of widespread and long-lasting molecular, cellular, and metabolic effects in the brain. Subjects in this urban cohort were likely exposed to chlorpyrifos at home, since many were born before or shortly after the US Environmental Protection Agency banned residential use of chlorpyrifos in 2001. The pesticide is still used in agriculture around the world. "Widespread exposures ... continue to place farm workers, pregnant women, and unborn children in harm's way," says senior author Virginia Rauh.
Note: Did you know that chlorpyrifos was originally developed by Nazis during World War II for use as a nerve gas? Read more about the history and politics of chlorpyrifos, and how U.S. regulators relied on falsified data to allow its use for years.
Important Note: Explore our full index to key excerpts of revealing major media news articles on several dozen engaging topics. And don't miss amazing excerpts from 20 of the most revealing news articles ever published.

